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ea0083domno2 | Diabetes, Obesity, Metabolism and Nutrition | EYES2022

Placental signalling contributes to adipokine dysregulation and systemic insulin resistance in gestational diabetes mellitus

C. J. McElwain , A Musumeci , S. Manna , I Sylvester , F. P. McCarthy , C. M. McCarthy

Background: Placental signalling has been postulated to drive inflammation, endothelial dysfunction and insulin resistance in gestational diabetes mellitus (GDM).Objectives: To determine if placental signalling contributes to systemic insulin resistance in GDM.Methods: Adiponectin, leptin, adipsin and resistin in placental and omental explant culture supernatants (n=10 GDM and n=10 control) and maternal plasma (n=20 GDM and n=20 co...

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ea0098c42 | Clinical – Nuclear Medicine/Interventional Radiology/Imaging | NANETS2023

Treatment with Lutetium in a real-world setting: How does it affect patient experience and their time-toxicity?

Romina Luca Maria , Cecilia Vazquez Eliana , Waisberg Federico , Catani Greta , Oviedo Ana , Musumeci Martina , Rodriguez Andres , Bortz Marcos , Esteso Federico , Chacon Matias , Manuel Oconnor Juan , Racioppi Silvina

Background: Lutetitum-177 (Lu-DOTATE) is an approved treatment regimen for patients with advanced neuroendocrine tumors (NETs). Improving patient experience is one of main goals of a cancer treatment plan. "Time-toxicity" describes the period that patients spend in doing administrative or medical procedures, including medical visits, scans, lab analyses, emergency room admissions, drug applications and hospitalizations. Modern therapies are usually approved after an im...

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Endocrine Abstracts

Placental signalling contributes to adipokine dysregulation and systemic insulin resistance in gestational diabetes mellitus

Treatment with Lutetium in a real-world setting: How does it affect patient experience and their time-toxicity?

BiosciAbstracts